Buy cheap Plavix - Clopidogrel without prescriptions needed. Free worldwide shippping. No hidden fee on Plavix - Clopidogrel. Plavix Clopidogrel Brand name: Plavix Why is Plavix prescribed? Plavix is used to reduce the risk of stroke or heart attack. It works by preventing excessive blood clotting. Clopidogrel bisulfate is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. How should Plavix be used? Plavix comes as a tablet to take by mouth. It usually is taken once a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Take Plavix exactly as directed. Tell your doctor if you are pregnant. You should not breast-feed while using this medicine. How should I take Plavix? Take Plavix exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Use these medicines exactly as directed. Plavix can be taken with or without food. Plavix is sometimes taken together with aspirin. Take aspirin only if your doctor tells you to. Plavix keeps your blood from coagulating clotting and can make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have any bleeding that will not stop.
You may need to stop using this medicine for a short time before a surgery, medical procedure, or dental work. Any healthcare provider who treats you should know that you are taking this medicine. Do not stop taking Plavix without first talking to your doctor, even if you have signs of bleeding. Stopping the medicine could increase your risk of a heart attack or stroke. Store at room temperature away from moisture and heat. Optimal duration unknown.
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Treating heartburn and GERD can be tricky in patients taking Plavix clopidogrel because of drug interactions with the medications used to treat those symptoms. H2 Blockers, the class of drugs that includes Zantac ranitidine , are okay to use. The exception is cimetidine which will interact with Plavix. This combination results in decreased effectiveness of Plavix, increasing the risk of heart attack or stroke. It is unclear if the other PPI drugs have the same effect and if it is to the same extent. Over-the-counter OTC antacids, such as Tums, may help somewhat. Always read and follow the complete directions and warnings on OTC medications and discuss their use with your healthcare provider before taking them.
Contact your healthcare provider to discuss your treatment options. I had a TIA and my doctor put me on Plavix. Is there any alternative to that expensive drug? A TIA transient ischemic attack is defined as a temporary block of blood flow to the brain caused by low blood flow, narrowing of the blood vessels, or a blood clot. The episode may last only a few minutes, but it may cause the patient to have slurred speech, changes in behavior, and memory or movement impairment. The cause of the TIA will determine which course of action to take. If your TIA was of unknown origin, then antiplatelet therapy is suggested with either aspirin, Plavix, or Aggrenox.
Plavix is usually the first-line therapy. If your TIA was caused by a known blockage, then most likely the physician would have you take Coumadin, a blood thinner, to tackle the problem. Coumadin brings with it a load of complications, interactions, and the need for regular blood monitoring; it may not be something you need. The best thing to do is have a discussion with your physician to see there are any options that would work for you. Lori Poulin, PharmD Q: I need a replacement for Plavix. Can you recommend anything? Only your physician can determine if an alternate anti-platelet medication can be right for you.
There are several others, including Aggrenox aspirin and dipyridamole , Effient prasugrel , Ticlid ticlopidine , and Pletal cilostazol. Each has its share of patient-specific side effects and interactions with other medications. Is there a medication that can take the place of Plavix that would be cheaper? Plavix clopidogrel is an antiplatelet medication, meaning that it helps keep platelets in the blood from sticking together and forming blood clots. Plavix does not come in generic form in the United States at this time. There are other medications that are antiplatelets, such as aspirin, dipyridamole, and ticlopidine.
However, these medications are not interchangeable. You shouldn't make any changes in your medication without talking to your doctor first. My 102 year old father has been put on Plavix. What are the possible side effects? Plavix clopidogrel bisulfate helps keep platelets in the blood from sticking together and forming clots, which are the direct cause of most heart attacks and strokes. It is recommended for people who have experienced a recent clot-related event, such as a heart attack or stroke, or who have been diagnosed with Peripheral Artery Disease PAD ; also known as poor circulation in the legs. In clinical trials, the most common side effects of Plavix were severe itching pruritus , a severe rash characterized by the appearance of purplish spots or patches purpura , diarrhea, and rash.
For more specific information, consult with your doctor or pharmacist for guidance based on your specific condition and current medications. Shereen A. Gharbia, PharmD Q: What would the interaction be between Plavix and Nexium? Plavix clopidogrel bisulfate is an oral antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Generally speaking, drug interactions fall into three main categories: Drug-drug i. Drug-disease interactions may occur when an existing medical condition makes certain drugs potentially harmful. Coadministration with proton pump inhibitors PPIs , such as Nexium esomeprazole may reduce the cardioprotective effects of clopidogrel.
Until further data is available, the use of proton pump inhibitors should preferably be avoided in patients treated with clopidogrel. PPIs should only be considered in high-risk patients such as those receiving dual antiplatelet therapy, those with a history of gastrointestinal bleeding or ulcers, and those receiving concomitant anticoagulant therapy, and then only after thorough assessment of risks versus benefits. If gastroprotection is necessary, H2-receptor antagonists or antacids should be prescribed whenever possible. I've been taking Plavix for 20 years.
It was prescribed after a heart attack. Should I stop? According to drug information, Plavix is prescribed to reduce the rate of atherothrombotic events such as heart attacks. Therefore, patients that have had a heart attack in the past are often kept on this medication. I would not discontinue the medication without talking to your physician first. As always, talk with your healthcare provider regarding questions you have about your medications. Jen Marsico RPh Q: I had a heart attack three weeks ago and was told that Plavix, that I had been on for 3 years, was not working for me. The cardiologist then doubled the dosage that I had been taking. Is there an alternative to Plavix?
In laymen's terms this is called making "platelets less sticky"; in medical terms this is called "inhibiting platelet aggregation". The end result is that people do not clot as easily and this effect is mainly seen in the arteries. Talk to your doctor to find out if an alternative medication is appropriate. For more specific information, consult with your doctor or local pharmacist for guidance based on your specific condition and current medications. If I am taking Plavix and low-dose aspirin, what other pain reliever can I take for headache or muscle pain that is safe? Plavix and aspirin are generally recommended to not be taken with NSAIDS non steroidal anti-inflammatory drugs due to an enhancement in antiplatelet effects and an increase in risk of bleeding with the respective drugs.
However, selection of which medication to take has many variables and needs to take into consideration any other medications or health conditions you may have. Please speak to your health care provider and ask if Tylenol would be an appropriate medication for you. My cardiologist said I shouldn't take omeprazole with Plavix. He switched me to Pepcid, which doesn't take care of my upset stomach. Any thoughts or suggestions? Unfortunately, your doctor is right. Nor can any of the other drugs that are in the same subcategory as omeprazole be used. If you are not getting adequate relief from Pepcid, perhaps you might want to discuss with your health care provider the possibility of changing to another product in the same class as Pepcid, such as Axid or Zantac, to see if they give you more relief.
It is always a good idea to check with one Q: I was placed on Plavix following a headache; however, it was not a stroke. I have been using it for a year. I am 67-year-old female. Will I have to always take it? It is usually used in patients that have a history of heart attack or stroke or in patients that have certain disorders of their blood vessels. I would speak to your prescribing physician regarding why you were put on the medication. Patients that are being treated for the above uses, will likely be on the medication for the long duration. Your physician could provide information about your treatment duration.
Jen Marsico, RPh Q: What are the pros and cons of taking Plavix and Prilosec together? Their review of available data indicate that the effectiveness of Plavix will be reduced by approximately half when combined with Prilosec. Patients at risk for heart attacks or strokes who use Plavix will not get the full anti-blood clotting effect when taken with Prilosec. Separating the doses of these two medications will not prevent this drug interaction. Other proton pump inhibitors PPIs , the class of drugs that includes Prilosec, may or may not have the same effect. Other stomach acid treatment options for patients on Plavix include antacids, like Maalox or Mylanta, and most acid reducers, including Zantac ranitidine , Pepcid famotidine , and Axid nizatidine.
However, Tagamet cimetidine should not be used. FDA recognizes that patients on Plavix frequently need medications to control stomach acid, like Prilosec. Therefore, they provide the following recommendations for patients on Plavix: Patients using clopidogrel should consult with their health care provider if they are currently taking or considering taking omeprazole, including Prilosec OTC. Both clopidogrel and omeprazole can provide significant benefits to patients, and patients should always consult with their health care professional before starting or stopping any medication. It is very important that patients talk with their health care professional about any over-the-counter OTC drugs they are taking before starting or while using clopidogrel Consult your health care provider for recommendations based on your specific circumstances.
This site is provided for informational and educational purposes only. You may not rely on this site for professional medical advice, diagnosis or treatment, pharmacist advice or any professional service requiring licensure, registration or certification in any state. Follow the instructions of your health care provider and read carefully all product packaging associated with any medication that is provided to you. Medication information offered on this site is for informational purposes only and is neither independently verified nor endorsed by Everyday Health, Inc. We cannot offer any assurances that any product is safe, effective or appropriate for you. If you are in need of medical attention, contact your physician or other health care provider or dial 911 if you believe that you are experiencing a medical emergency.
Is Plavix supposed to smell like vinegar? Plavix clopidogrel is used to reduce the risk of stroke or heart attack in patients who have already had a heart attack or stroke or in patients who have other heart and circulatory problems. There is no information about Plavix smelling like vinegar. For other drugs, like aspirin, a strong vinegar-like smell can indicate that the drug is breaking down and should not be used. Please contact your local pharmacist to examine the medication and determine the appropriate course of action. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.
Plavix is used to reduce the risk of stroke or heart attack. It works by preventing excessive blood clotting. Clopidogrel bisulfate is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. How should Plavix be used? Plavix comes as a tablet to take by mouth. It usually is taken once a day. More What is Plavix? Plavix clopidogrel prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery. Plavix is used to lower your risk of having a stroke , blood clot, or serious heart problem after you've had a heart attack , severe chest pain angina , or circulation problems.
Plavix may also be used for purposes not listed in this medication guide. Important Information Plavix keeps your blood from coagulating clotting to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions. Because of this drug action, Plavix can make it easier for you to bleed, even from a minor injury. You should not use this medicine if you have any active bleeding such as a stomach ulcer or bleeding in the brain. Plavix increases your risk of bleeding, which can be severe or life-threatening. This action is irreversible. Consequently, platelets exposed to clopidogrel's active metabolite are affected for the remainder of their lifespan about 7 to 10 days.
Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP. Dose-dependent inhibition of platelet aggregation can be seen 2 hours after single oral doses of Plavix. Repeated doses of 75 mg Plavix per day inhibit ADP-induced platelet aggregation on the first day, and inhibition reaches steady state between Day 3 and Day 7. Platelet aggregation and bleeding time gradually return to baseline values after treatment is discontinued, generally in about 5 days. Hepatically Impaired Patients After repeated doses of 75 mg Plavix per day for 10 days in patients with severe hepatic impairment, inhibition of ADP-induced platelet aggregation was similar to that observed in healthy subjects.
Gender In a small study comparing men and women, less inhibition of ADP-induced platelet aggregation was observed in women. Pharmacokinetics Clopidogrel is a prodrug and is metabolized to a pharmacologically active metabolite and inactive metabolites. Absorption After single and repeated oral doses of 75 mg per day, clopidogrel is rapidly absorbed. Effect of food Plavix can be administered with or without food. Similar results were observed when a Plavix 300 mg loading dose was administered with a high-fat breakfast. Metabolism Clopidogrel is extensively metabolized by two main metabolic pathways: Cytochromes first oxidize clopidogrel to a 2-oxo-clopidogrel intermediate metabolite.
Subsequent metabolism of the 2-oxo-clopidogrel intermediate metabolite results in formation of the active metabolite, a thiol derivative of clopidogrel. The active thiol metabolite binds rapidly and irreversibly to platelet receptors, thus inhibiting platelet aggregation for the lifespan of the platelet. The Cmax of the active metabolite is twice as high following a single 300 mg clopidogrel loading dose as it is after four days of 75 mg maintenance dose. Cmax occurs approximately 30 to 60 minutes after dosing. In the 75 to 300 mg dose range, the pharmacokinetics of the active metabolite deviates from dose proportionality: After a single, oral dose of 75 mg, clopidogrel has a half-life of approximately 6 hours.
The half-life of the active metabolite is about 30 minutes. Concomitant use of certain inhibitors of this enzyme results in reduced plasma concentrations of the active metabolite of clopidogrel and a reduction in platelet inhibition. Proton pump inhibitors PPI The effect of proton pump inhibitors PPI on the systemic exposure to the clopidogrel active metabolite following multiple doses of Plavix 75 mg evaluated in dedicated drug interaction studies is presented in Figure 1. Figure 1:
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