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Also tell your doctor if you are taking an antidepressant such as citalopram Celexa , desvenlafaxine Pristiq , duloxetine Cymbalta , escitalopram Lexapro , fluoxetine Prozac, Sarafem , fluvoxamine Luvox , paroxetine Paxil , sertraline Zoloft , or venlafaxine Effexor. Imitrex will only treat a headache that has already begun. Do not use Imitrex within 24 hours before or after using any other migraine headache medicine. Before taking this medicine You should not use Imitrex if you are allergic to sumatriptan, or if you have ever had: Do not use Imitrex if you have used an MAO inhibitor in the past 14 days.

A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Tell your doctor if you have ever had: It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Sumatriptan can pass into breast milk. Do not breast-feed within 12 hours after using Imitrex. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

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With proper education, children begin to ask for a pot when a urge to urinate with a 1-year-old. Diabetes, which has an adverse effect on life quality and lifespan by progressing silently when not diagnosed, is a disease of which the rate of incidence has been on the rise lately. In such cases, you should always think about cancer. In this case, there is a destruction of tissue and, to a lesser extent, cellular structures. The use of Imitrex tablets in this population is contraindicated [see Contraindications 4 , Use in Specific Populations 8. Male and Female Patients: Racial Groups: Oral sumatriptan has not been evaluated for race differences. Treatment with MAO-A inhibitors generally leads to an increase of sumatriptan plasma levels [see Contraindications 4 , Drug Interactions 7.

Due to gut and hepatic metabolic first-pass effects, the increase of systemic exposure after coadministration of an MAO-A inhibitor with oral sumatriptan is greater than after coadministration of the MAO inhibitors with subcutaneous sumatriptan. A small trial evaluating the effect of pretreatment with an MAO-A inhibitor on the bioavailability from a 25-mg oral sumatriptan tablet resulted in an approximately 7-fold increase in systemic exposure. Alcohol consumed 30 minutes prior to sumatriptan ingestion had no effect on the pharmacokinetics of sumatriptan. There was no evidence in either species of an increase in tumors related to sumatriptan administration. It is not clear whether this finding was due to an effect on males or females or both.

Plasma exposure at the lowest dose tested was approximately 2 times that in humans at the MRHD. Clinical Studies The efficacy of Imitrex tablets in the acute treatment of migraine headaches was demonstrated in 3, randomized, double-blind, placebo-controlled trials. Patients were instructed to treat a moderate to severe headache. Associated symptoms such as nausea, photophobia, and phonophobia were also assessed. The frequency and time to use of these additional treatments were also determined. There were no statistically significant differences between the 50-mg and 100-mg dose groups in any trial. Imitrex is not approved for use by anyone younger than 18 years old.

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