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In order to reduce this risk, Clopidogrel can be given. As a so-called platelet aggregation inhibitors preventing rapid aggregation of platelets by blocking the signal transduction of the neurotransmitter Adenosinphophat to the platelets. So too rapid blood clotting is inhibited. This reduces the risk of a heart attack or stroke is reduced efficiently by Clopidogrel. Up, degradation and excretion of Clopidogrel After taking over her mouth Clopidogrel is taken only to about 50 percent from the intestine into the blood. Then the drug substance in the liver must be activated before it can exert its effect.

The reduction takes place in the liver; the degradation products are excreted via the kidneys and the chair. When will Clopidogrel used? The fields of application indications of Clopidogrel are: This is usually done on tablets and with or without food. The usual daily dose for adults is 75 milligrams. It may be useful to combine Clopidogrel with other drugs in order to intensify the effect. Often there is a combination with acetylsalicylic acid. The two drugs have different points of attack on the anticoagulants which the clustering of platelets delayed even more efficiently.

A stent is a small tube which the unimpeded blood flow ensures in narrow blood vessels when a patient has an increased risk of heart attack or stroke. What are the side effects of Clopidogrel? Often that is, at one to ten percent of patients calls Clopidogrel side effects such as bruising, bleeding in the gastrointestinal tract and general gastrointestinal symptoms such as, dizziness, eye bleeding, gastrointestinal ulcers, skin lesions, blood in urine and prolonged bleeding time. What should be considered when taking Clopidogrel? Contraindications Patients who suffer from severe hepatic impairment or acute pathological bleeding, Clopidogrel should not take.

Limitations The Clopidogrel effect lasts for several days. Therefore, elective surgery including dental surgery is previously discontinued the drug a week in consultation with the doctor. Patients who are suffering from kidney or liver problems, should keep before taking Clopidogrel consultation with the doctor, because to date, very few data were collected. Some people are so-called slow metabolizers of CYP2C19. For them, the active ingredient in the liver is slowed only enabled, significantly reducing its effect. Use of certain tests can predict the efficacy of Clopidogrel. Interaction The effects and side effects of Clopidogrel are other blood-thinning agents such as aspirin, heparin, abciximab, eptifibatide, tirofiban strengthened.

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