Here you can read everything about the effect of Allopurinol, side effects and use. Pharmachologic effect A drug that interferes with the synthesis of uric acid. It is a structural analogue of hypoxanthine. It inhibits the enzyme xanthine oxidase, which is involved in the conversion of hypoxanthine to xanthine and xanthine into uric acid. This explains that they can not be used to protect against infection and prevent their infection in tissues and kidneys. When taking Allopurinol, the excretion of urine hypoxanthine and xanthine increases. Metabolized with the formation of alloxanthin, which retains the ability to inhibit xanthine oxidase long enough.
Cmax of Allopurinol in blood plasma, after an average of 1. Indications Treatment and prevention of gout and hyperuricemia of various genesis including in combination with nephrolithiasis, renal insufficiency, urate nephropathy. Recurrent mixed oxalate-calcium kidney stones in the presence of hyperuricosuria. Increased urate formation after enzymatic disorders. Prophylaxis of acute nephropathy in cytostatic and radiation therapy of tumors and leukemia, as well as with complete medical starvation. Dosing Established individually, controlled by the concentration of urate and uric acid in the blood and urine. Maximum doses: An increase in the dose is possible in those cases when, on the background of the therapy, an increased concentration of urate in the blood and urine remains.
Side effect From the cardiovascular system: From the digestive system: From the side of the central nervous system and the peripheral nervous system: On the part of the hematopoiesis system: From the urinary system: On the part of the endocrine system: From the side of metabolism: Allergic reactions: Dermatological reactions: How does Allopurinol work? The structure of the drug Allopurinol is very similar to that of hypoxanthine, a degradation product of nucleic acid metabolism nucleic acids are the building blocks of the genetic material. This hypoxanthine is converted by an enzyme, xanthine oxidase, into uric acid, which is excreted through the kidneys into the urine. Where to Buy Etoricoxib Arcoxia 60, 90, 120 mg UK If accumulates too much uric acid in the body due to disease or malnutrition meat-rich diet , this crystallizes.
The crystals are deposited mainly in the joints, where they cause inflammation, a movement restriction and pain — doctors speak then of gout. Also in the kidney are uric acid crystals can deposit gout kidney. Allopurinol blocks the enzyme xanthine oxidase, and thus the degradation of hypoxanthine to uric acid. The precursors of uric acid can also be excreted via the kidneys, however: In the body Allopurinol is almost completely converted within two hours after ingestion in oxypurinol, but both forms inhibit the enzyme in question. Oxypurinol is excreted very slowly for 18 to 43 hours via the kidneys in the urine.
What is Allopurinol used for? The drug Allopurinol is used in adults as a drug of first choice for the treatment of hyperuricemia elevated uric acid levels in the blood used, which makes usually only by secondary diseases such as gout, kidney stones and other kidney ailments noticeable. However, initiation of therapy should always be tried before that to get high purine or uric acid levels by diet under control, such as a meat-free diet. The therapy with Allopurinol is usually long term, provided that the uric acid levels do not normalize by the change in diet. Allopurinol but is only suitable as a preventive measure of acute gout attacks sudden severe, inflammatory , but not for the treatment of a seizure — taking during a seizure may increase the acute pain.
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How to take colchicine Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about colchicine and will provide you with a full list of the side-effects which you may experience from taking it. You must take colchicine exactly as your doctor tells you to. Most doctors will recommend that when a gout attacks starts, you should take one tablet 2-4 times a day until the pain eases. It is important that you do not take more than 12 tablets of colchicine as a course of treatment during any one gout attack. It is also important that you leave at least three days between courses of colchicine.
If you find you are having frequent attacks of gout, please let your doctor know about this. If you have recently been prescribed a medicine to prevent gout attacks such as allopurinol, febuxostat, or sulfinpyrazone and you have been given colchicine to prevent a flare-up attack of gout, the usual dose for this is one tablet twice each day. Take colchicine tablets with a drink of water. If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Getting the most from your treatment Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Do not drink grapefruit juice while you are on colchicine. This is because grapefruit juice increases the risk that you will experience side-effects from the colchicine. Colchicine tablets are taken in short courses of treatment to relieve the pain of a gout attack. There are a number of lifestyle changes that you can make to help reduce the risk of having a gout attack. These include losing weight if you are overweight , eating a healthy diet and not drinking much alcohol or sugar-sweetened soft drinks.
Your doctor will advise you about the changes which could benefit you. Never take more than the prescribed dose. For this purpose, usually once a day started with a hundred milligrams of Allopurinol and then gradually increased if needed. The maximum Allopurinol dose per day is eight hundred milligrams, which in several doses morning, noon, evening is split. Because Allopurinol inhibits the formation of uric acid, it is referred to as Urikostatikum. In severe cases, a uricosuric can additionally be given a drug that promotes the excretion of uric acid eg, probenecid or benzbromarone.
There are also tablets that already contain both active substances Allopurinol and uricosuric. What are the special instructions for taking Allopurinol? For patients with existing liver or kidney disease specific dosage recommendations apply. When and heart failure congestive heart failure Allopurinol may only be used very carefully, as this may renal function is limited. This can be achieved by adding sufficient liquid is drunk. Allopurinol may interact with various medications. In combination with antibiotics such as Ampicillin and can increasingly rashes occur.
With simultaneous application of cytostatics cancer drugs occur more frequently blood disorders. This must be especially monitored. Allopurinol can the degradation of drugs such as Phenytoin at , chlorpropamide inhibit in diabetes and ciclosporin for autoimmune diseases and after transplants. Their dose must therefore possibly be reduced by the doctor. During pregnancy and lactation Allopurinol should not be used, since this requires the data are insufficiently. In addition, the drug has been shown in animal studies as a reproductive prejudicial toxic for reproduction. How to buy medication with Allopurinol?
All medicines containing the active substance Allopurinol require a prescription because of the wide-ranging interactions with other drugs and to apply only through the pharmacy. But you can buy Allopurinol tablets online from UK. Since when Allopurinol is known? Allopurinol was first approved in the US in the year 1966th After the patent had expired, numerous generic preparations of the original generic came on the market. In 1977, the active ingredient of the World Health Organization WHO has been added to the list of essential medicines. This list includes all active ingredients that are needed to provide the most urgent needs of the population to health care satisfied.
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