The possibility exists of exacerbation or activation of systemic lupus erythematosus. As with many other drugs, patients should be observed regularly for the possible occurrence of blood dyscrasias, liver or kidney damage, or other idiosyncratic reactions. The postural hypotension that sometimes occurs can usually be managed by getting up slowly. Patients with diabetes mellitus should be told that furosemide may increase blood glucose levels and thereby affect urine glucose tests. The skin of some patients may be more sensitive to the effects of sunlight while taking furosemide. Hypertensive patients should avoid medications that may increase blood pressure, including over-the-counter products for appetite suppression and cold symptoms.
Laboratory Tests Serum electrolytes particularly potassium , CO2, creatinine and BUN should be determined frequently during the first few months of Lasix therapy and periodically thereafter. Serum and urine electrolyte determinations are particularly important when the patient is vomiting profusely or receiving parenteral fluids. Abnormalities should be corrected or the drug temporarily withdrawn. Other medications may also influence serum electrolytes. Reversible elevations of BUN may occur and are associated with dehydration, which should be avoided, particularly in patients with renal insufficiency. Urine and blood glucose should be checked periodically in diabetics receiving Lasix, even in those suspected of latent diabetes.
Lasix may lower serum levels of calcium rarely cases of tetany have been reported and magnesium. Accordingly, serum levels of these electrolytes should be determined periodically. Pediatric Use. Drug Interactions Lasix may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination. Lasix should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with Lasix, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.
There is a risk of ototoxic effects if cisplatin and Lasix are given concomitantly. In addition, nephrotoxicity of nephrotoxic drugs such as cisplatin may be enhanced if Lasix is not given in lower doses and with positive fluid balance when used to achieve forced diuresis during cisplatin treatment. Lasix has a tendency to antagonize the skeletal muscle-relaxing effect of tubocurarine and may potentiate the action of succinylcholine. Lasix combined with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers may lead to severe hypotension and deterioration in renal function, including renal failure. An interruption or reduction in the dosage of Lasix, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers may be necessary.
Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs. Lasix may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively. Simultaneous administration of sucralfate and Lasix tablets may reduce the natriuretic and antihypertensive effects of Lasix. The intake of Lasix and sucralfate should be separated by at least two hours. In isolated cases, intravenous administration of Lasix within 24 hours of taking chloral hydrate may lead to flushing, sweating attacks, restlessness, nausea, increase in blood pressure, and tachycardia. Use of Lasix concomitantly with chloral hydrate is therefore not recommended.
Phenytoin interferes directly with renal action of Lasix. There is evidence that treatment with phenytoin leads to decreased intestinal absorption of Lasix, and consequently to lower peak serum furosemide concentrations. Methotrexate and other drugs that, like Lasix, undergo significant renal tubular secretion may reduce the effect of Lasix. Conversely, Lasix may decrease renal elimination of other drugs that undergo tubular secretion. Lasix can increase the risk of cephalosporin-induced nephrotoxicity even in the setting of minor or transient renal impairment. Concomitant use of cyclosporine and Lasix is associated with increased risk of gouty arthritis secondary to Lasix-induced hyperurecemia and cyclosporine impairment of renal urate excretion.
One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency. There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs. Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of Lasix furosemide in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation.
Carcinogenesis, Mutagenesis, Impairment of Fertility Furosemide was tested for carcinogenicity by oral administration in one strain of mice and one strain of rats. A small but significantly increased incidence of mammary gland carcinomas occurred in female mice at a dose 17. Furosemide was devoid of mutagenic activity in various strains of Salmonella typhimurium when tested in the presence or absence of an in vitro metabolic activation system, and questionably positive for gene mutation in mouse lymphoma cells in the presence of rat liver S9 at the highest dose tested. Furosemide did not induce sister chromatid exchange in human cells in vitro, but other studies on chromosomal aberrations in human cells in vitro gave conflicting results.
In Chinese hamster cells it induced chromosomal damage but was questionably positive for sister chromatid exchange. Studies on the induction by furosemide of chromosomal aberrations in mice were inconclusive. The urine of rats treated with this drug did not induce gene conversion in Saccharomyces cerevisiae. Pregnancy Furosemide has been shown to cause unexplained maternal deaths and abortions in rabbits at 2, 4 and 8 times the maximal recommended human dose. There are no adequate and well-controlled studies in pregnant women.
Lasix should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Treatment during pregnancy requires monitoring of fetal growth because of the potential for higher birth weights. The effects of furosemide on embryonic and fetal development and on pregnant dams were studied in mice, rats and rabbits. Data from the above studies indicate fetal lethality that can precede maternal deaths. The results of the mouse study and one of the three rabbit studies also showed an increased incidence and severity of hydronephrosis distention of the renal pelvis and, in some cases, of the ureters in fetuses derived from the treated dams as compared with the incidence in fetuses from the control group.
If you experience any of the following symptoms, call your doctor immediately: Why is this medication prescribed? Furosemide is used alone or in combination with other medications to treat high blood pressure. Furosemide is used to treat edema fluid retention; excess fluid held in body tissues caused by various medical problems, including heart, kidney, and liver disease. Furosemide is in a class of medications called diuretics 'water pills'. It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine. High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body.
Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation. How should this medicine be used? Furosemide comes as a tablet and as a solution liquid to take by mouth. It usually is taken once or twice a day. When used to treat edema, furosemide may be taken daily or only on certain days of the week.
When used to treat hypertension, take furosemide around the same time s every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take furosemide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Furosemide controls high blood pressure and edema but does not cure these conditions. Continue to take furosemide even if you feel well. Do not stop taking furosemide without talking to your doctor. Other uses for this medicine This medicine is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
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LASIX ® (furosemide) Tablets 20, 40, and 80 mg WARNING. LASIX ® (furosemide) is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. if you are taking sucralfate (Carafate), take it 2 hours before or after you take furosemide. tell your doctor if you have kidney disease. Your doctor may tell you not to take furosemide. 2/24/ · Furosemide belongs to a group of medicines called loop diuretics.A diuretic is a medicine which increases the amount of urine that you pass out from . A: There are different diabetes medications, so we would need to know the specific names to give the side effects, but Lasix (furosemide) for hypertension (high blood pressure) does have specific.
If you experience any of the following symptoms, call your doctor immediately: Why is this medication prescribed? Furosemide is used alone or in combination with other medications to treat high blood pressure. Furosemide is used to treat edema fluid retention; excess fluid held in body tissues caused by various medical problems, including heart, kidney, and liver disease. Furosemide is in a class of medications called diuretics 'water pills'. It works by causing the kidneys to get rid of unneeded water and salt from the body into the urine.
High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. Follow your doctor's instructions about using potassium supplements or getting enough salt and potassium in your diet. While using Lasix, you may need frequent blood tests. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms.
You may need to use blood pressure medicine for the rest of your life. If you need surgery, tell the surgeon ahead of time that you are using Lasix. Store at room temperature away from moisture, heat, and light. Throw away any Lasix oral solution liquid 90 days after opening the bottle, even if it still contains unused medicine. See also: Lasix dosage information in more detail What happens if I miss a dose? It has been demonstrated that Lasix inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubu but also in the loop of Henle. The high degree of efficacy is largely due to the unique site of action.
The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone. Recent evidence suggests that furosemide glucuronide is the only or at least the major biotransformation product of furosemide in man. Furosemide is extensively bound to plasma proteins, mainly to albumin. The unbound fraction averages 2. The onset of diuresis following oral administration is within 1 hour. The peak effect occurs within the first or second hour. The duration of diuretic effect is 6 to 8 hours. Although furosemide is more rapidly absorbed from the oral solution 50 minutes than from the tablet 87 minutes , peak plasma levels and area under the plasma concentration-time curves do not differ significantly.
Peak plasma concentrations increase with increasing dose but times-to-peak do not differ among doses. The terminal half-life of furosemide is approximately 2 hours. Significantly more furosemide is excreted in urine following the IV injection than after the tablet or oral solution. There are no significant differences between the two oral formulations in the amount of unchanged drug excreted in urine. Geriatric Population Furosemide binding to albumin may be reduced in elderly patients. Furosemide is predominantly excreted unchanged in the urine. Geriatric Use.
Indications and Usage for Lasix Edema Lasix is indicated in adults and pediatric patients for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Lasix is particularly useful when an agent with greater diuretic potential is desired. Hypertension Oral Lasix may be used in adults for the treatment of hypertension alone or in combination with other antihypertensive agents. Hypertensive patients who cannot be adequately controlled with thiazides will probably also not be adequately controlled with Lasix alone. Contraindications Lasix is contraindicated in patients with anuria and in patients with a history of hypersensitivity to furosemide.
The table below contains some of the more common ones associated with furosemide. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome. Furosemide side-effects What can I do if I experience this? Feeling sick, stomach upset This is usually mild, but it may help to take furosemide after food Feeling dizzy, particularly when you stand up due to low blood pressure Getting up and moving more slowly should help.
Do not drive and do not use tools or machines while affected Dry mouth Try chewing sugar-free gum or sucking sugar-free sweets Blurred vision, headache, feeling tired If any of these become troublesome, speak with your doctor Changes to the levels of minerals in your body Your doctor will ask you to have blood tests to check for this If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice. How to store furosemide Keep all medicines out of the reach and sight of children. Store in a cool, dry place, away from direct heat and light.
Important information about all medicines Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty. This medicine is for you. Never give it to other people even if their condition appears to be the same as yours. I don't drink a lot of water, but with the liquids I am drinking, why don't I go to the bathroom more than I do? Lasix generic name furosemide is called a loop diuretic.
Loop diuretics make the kidneys eliminate larger amounts of electrolytes such as sodium and potassium salts and water than normal. Loop diuretics treat edema and swelling. Side effects of Lasix include dizziness, cramping, muscle spasms. Lab work should be done by a physician regularly to control potassium levels. Loop diuretics should not cause excessive thirst or urination. If Lasix does not seem to effectively be working, consult with a physician about other treatment options. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition. This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis.